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Clinical trial for the treatment of early CRPS I and II
(Complex Regional Pain Syndromes I and II or
Reflex Sympathetic Dystrophy and Causalgia)
A National Institutes of Health Study
The National Institutes of Health is seeking patients who have been recently
diagnosed with Complex Regional Pain Syndromes I or II (CPRS I or II) for a
clinical trial of a potential new treatment for these painful disorders. These
conditions were formerly known as Reflex Sympathetic Dystrophy or Causalgia.
This study (NIH Protocol 00-D-0200) is a collaborative effort involving
investigators in the National Institute of Neurological Disorders and Stroke
(NINDS), National Institute of Dental and Craniofacial Research (NIDCR), and
Rehabilitation Medicine Department at NIH. The study is designed to evaluate the
efficacy of Neurotropin as a treatment for early cases of CRPS I or II.
Neurotropin is a medication that is currently used in Japan to treat RSD and
other painful conditions and has been reported to be most effective in treating
recently diagnosed cases of CRPS I or II. Therefore, this initial study will
focus on patients who have recently (within the last year) develope
d pain in one limb that has been diagnosed as CRPS I or II. Subjects are now
being recruited for this outpatient, double blind, placebo-controlled cross-over
study. The study requires 11-12 weeks with 3 or 4 short visits to the N.I.H.
Clinical Center. Eligible patients will be reimbursed for travel and other
expenses, continue on their current medications as well as the experimental
agents and will receive optimal medical care at no cost. The patient and/or the